The activation of AMPK slows the synthesis of biomolecules to focus on conserving the cells energy. This shift in metabolism promotes the degradation of lipid droplets as a viable source of energy. To test how this impacts lipid droplet localization and cellular functions, we used an Oil-red-O stain to visualize lipid droplets. We find AMPK mediates a shift in lipid droplet distribution to the cell periphery and this is accompanied by enhanced cell migration.
AMPK regulates lipid metabolism and cell migration
by Xianzhen Zhou, Andrew Basht, Jennifer Bekker, Dillan Brown and Amanda McCormick
Health and Life Sciences