The activation of AMPK slows the synthesis of biomolecules to focus on conserving the cells energy. This shift in metabolism promotes the degradation of lipid droplets as a viable source of energy. To test how this impacts lipid droplet localization and cellular functions, we used an Oil-red-O stain to visualize lipid droplets. We find AMPK mediates a shift in lipid droplet distribution to the cell periphery and this is accompanied by enhanced cell migration.