The objective was to assess the effects of intrauterine dextrose infusion after calving on uterine health, metabolic stress, and inflammation in dairy cows. Cows (n=135) were randomly assigned to groups: SAL: intrauterine infusion of saline solution; DEX: intrauterine infusion of 50% dextrose solution, or CON: untreated. Uterine health and blood metabolites were assessed at 7, 14 and 21 d after. SAL cows had higher clinical metritis incidence and metabolic stress and inflammation at day 7