by Karah Shultz
Antibiotics that exist on the market today are causing bacterial resistance. Recently, the binding sites of KKL-35 and KKL-55 , classified as an oxadiazole and tetrazole respectively, have been visually verified by cryogenic electron microscopy (cryo-EM). These proposed binding sites for KKL-35 and KKL-55 can be further confirmed by exploring how other antibiotics, with known binding sites, interact with KKL-35 and KKL-55. The interactions are measuring synergy, which verified the binding site.
Health and Life Sciences