Diffuse intrinsic pontine glioma (DIPG) is a pediatric cancer characterized by a low survival rate, creating a pressing need for novel therapeutics. After discovering that the hyperactivation of the mitochondrial ClpP protease reduces DIPG tumor growth, a library of natural products was screened for chemotherapeutic potential. Utilizing cell viability assays, two compounds able to reduce DIPG tumor cell viability in culture were identified. Such results present great promise for the future development of cancer treatments.