Latinx college students experience unique risk factors related to risky alcohol use and consequences. Longitudinal associations were examined between acculturation, enculturation, and drinking/consequences among Latinx students (N=245; Mage=18.27; 73% female). Structural equation modeling was used to analyze these associations. Enculturation was directly associated with consequences. The interaction between acculturation and enculturation was indirectly associated with consequences through drinking. Culturally sensitive interventions could address enculturation to reduce risky drinking in Latinx students.