Examining the physiological role of ArfB through ribosome profiling in Caulobacter crescentus

by Emma Osterhaus
The trans-translation pathway is a new drug target for the discovery of novel antimicrobials. ssrA encodes a protein essential for functionality of trans-translation, which is an essential pathway for virulence in pathogenic bacteria. ArfB is an alternate factor for rescuing stalled ribosomes. Since deletion of arfB combined with deletion of ssrA is lethal, it presents a suitable target for drug discovery. His-tagged ArfB bound to ribosomes will be isolated for further ribosome profiling.
Major: 
Biochemistry and Molecular Biology
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Kenneth Keiler
Poster Number: 
15283