Epithelial-mesenchymal transition (EMT) is a process of normal epithelial cells losing cell polarity and cell to cell adhesion to become mesenchymal cells, but it also contributes to cancer progression. To test how drugs targeting cancer metabolism impact EMT, we analyzed effects on epithelial MDCK cells and mesenchymal MDA-231 cell lines. We find that inhibiting glycolysis can modulate mesenchymal phenotypes and cell migration.