Antibiotic resistance is an increasingly dangerous threat as pathogens develop resistance to currently available antibiotics. Natural products derived from soil samples were screened for their antibacterial properties against multiple species of bacteria. A genetically engineered fluorescence reporter strain was constructed to express a red fluorescence protein to help determine the mechanism of action for the antimicrobial compounds. Initial data shows that compounds DMM-EA-002, DMM-EA-003, and DMM-EA-004 inhibit translation in vitro and kill Bacillus anthracis cells.