Drug-resistant bacteria pose a serious global problem that requires urgent resolution through the discovery of new antibiotics. Extracts obtained from soil samples in Pennsylvania were tested for their antibacterial properties. Microbial inhibition assays identified natural products that killed Bacillus anthracis, a Gram-positive species of bacteria that causes Anthrax. These compounds inhibited translation in a similar manner to known antibiotics. The discovery of new compounds with antibacterial properties would help to fight infections from drug-resistant bacteria.