Metastasis of cancer cells can be promoted by epithelial to mesenchymal transition (EMT) and migration. Targeting cancer cell metabolism with the PFK-158 glycolytic inhibitor would be expected to decrease cancer cell proliferation, but it is not known how this impacts cell migration. Recent studies suggest that cells can use lipid droplet energy stores to fuel rapid migration. We find PFK-158 alters lipid metabolism, increases migration, and alters cell morphology.