The surge of micro-thin two-dimensional materials (2DMs) provides a promising outlook on a wide variety of applications in radiation hard environments such as space radiation environment, high-altitude flights, and particle accelerators. They offer a relatively new set of unique chemical/physical attributes which includes bandgap tunability, chemical composition variation, and high Young’s modulus despite their atomically thin and light structure. This paper focuses on the review of the effects of proton-irradiation on MoS2, WSe2, and Graphene.