Microtubule organization is crucial to neuronal growth and neurodegenerative disease mechanisms since microtubules comprise the core structure of neuronal components. Proteins involved in this organization localize at dendritic branchpoints, however, the signaling pathways controlling their targeting are unclear. Four receptor proteins act upstream of localizing microtubule regulators in dendrites, some concentrating in branchpoint endosomes. We therefore hypothesize that clathrin-mediated endocytosis internalizes receptors after they encounter cell-surface ligands. Clathrin localization to branchpoint structures supports this hypothesis.