Heart disease causes 25% of deaths worldwide. The continued discovery of new medications to treat heart diseases is thus essential for preserving human life. Ca2+/calmodulin-dependent protein kinase II (CaMKII) and serine/threonine protein kinase 1 (SGK1) are two enzymes associated with severe heart conditions. Computational methods were employed to screen for inhibitors of these enzymes. Three compounds were found to bind with high affinity within the active site of each enzyme, potentially inhibiting their function.