Cannabinoid pharmacology in post-traumatic stress disorder (PTSD)-like fear-memory behavior

Endocannabinoids regulate negative feedback neurotransmitters in PTSD fear-memory; whether phytocannabinoids modulate fear-memory is unconfirmed. We hypothesize Cannabis extracts containing the phytocannabiniod Cannabidiol reduce long-term fear-memory in mouse models and phytomolecules like cannabigerol, terpenes, and delta-9-tetrahydrocannabinol improve Cannabidiol efficacy through “entourage” effects. Findings suggest specific phytomolecule interactions are critical for entourage effects to Cannabidiol reducing fear-memory. High terpene content was not beneficial. Phytocannabinoids may be potential PTSD treatment options but more studies are necessary.