Characterization of Ruminococcus gnavus Lipoprotein Structure and Toll-Like Receptor Activity

The interaction between the human body and its gut microbiome is an area of interest in regard to human health. The detection of bacterial lipoproteins by host Toll-Like Receptors is a key part of this interaction. Ruminococcus ganvus is an anaerobic, gram-positive firmicute residing in approximately 90% of human gut microbiomes. This research characterizes the lipoprotein structure in R. gnavus and measures its ability to induce a TLR response in HEK293T cells.