Chromatin Remodeler Modulator CDCA7L

Cell Division Cycle Associated 7 (CDCA7) is a transcription factor containing a 4CXXC-type zinc finger domain mediated by c-Myc. In vivo, CDCA7 will first associate with chromatin; then, it will recruit LSH-1 and forms a complex. Mutations in CDCA7 or LSH-1 can result in DNA methylation defection, which is one of the main causes of ICF and many cancers. In my research, I'll be presenting CDCA7L purification research process and determining structure through electron microscopy.