Our lab is focusing on the anticancer activities of the following flavonoids: naringenin, quercetin, apigenin, eriodictyol, fisetin, and chrysin against oral cancer. We have found that their cytotoxic effects on oral cancer cells are different. To understand the mechanisms behind these differences, we obtained quantitative cell uptake of each flavonoid by SCC-25 cells and compared them via One-way ANOVA. The results showed that the cell uptake does not predict cytotoxicity of these flavonoids.