Impairment of the purine metabolism bifunctional enzyme adenylosuccinate lyase results in a rare disorder (ASLD). Due to the conservation of purine metabolism, we used C. elegans to examine the function of ADSL under neuron and muscle tissue-specific expression. We measured the animals' response to paralytic drugs known to cause overstimulation of muscle tissue. Overall, the results suggest ADSL expression is needed in the muscle and neuron.