Abriana Cain
Developing strategies to prevent metastatic disease is key to reducing mortality from breast cancer. Gene expression and immunohistochemistry were used to quantify hypoxia and vessel normalization within the tumors of physically active and energy restricted mice. Only the combination of physical activity and energy restriction significantly reduced gene expression of HIF-1α in the tumor microenvironment of this metastatic breast cancer model. Quantification of vessel normalization is in progress.