This study focuses on an RNA-binding motif protein 8A gene (RBM8A), or y14, and its effect on gene regulation in Huntington’s Disease.  y14 functions at the protein level to correct and degrade misfolded proteins; it is possible that y14, when overexpressed, can reduce the aggregates formed in patient brains. We will test the effect of y14 on aggregates formed by Huntington’s disease both in vitro and in vivo to determine its potential uses for treatment.