This thesis evaluates different epigenetic mechanisms’ contribution to health-related outcomes arising from child abuse exposure and the management of subsequent diseases linked to child abuse. Results from a semi-structured interview show that evolutionary perspectives can help understand epigenetic modifications, and increased telomere erosion rates worsen the outcomes for child abuse. Accurate screening tests can help improve abuse-related trauma management. This study shares insights on why epigenetics matters when managing patients that have survived childhood maltreatment.