Fatty acid uptake and CD36 overexpression promote epithelial-to-mesenchymal transition

Jingze Xu

Many cancers exhibit changes in lipid metabolism and expression of CD36, a key mediator of fatty acid uptake. Our group explored whether CD36-mediated fatty acid uptake could promote EMT, which is implicated in cancer progression.  We hypothesized that CD36 overexpression and oleic acid treatment would promote EMT by inducing lipid droplet formation and downregulating E-cadherin expression. We find that doxycycline-inducible CD36 overexpression and oleic acid increase lipid droplet formation while decreasing E-cadherin expression.

Major: 
Immunology and Infectious disease
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Emily Bell
Poster Number: 
16815