Genetic variation dopamine transporter gene (SLC6A3) is associated with multiple neuropsychiatric disorders. Two tandem repeats that are GC rich were identified. These sequences can form G-Quadruplexes (G4s), which can interfere with normal genomic function. QGRS Mapper software predicted that these tandem repeats could form G4s, which was confirmed with circular dichroism (CD) spectroscopy. This finding could have implications for gene expression, splicing, or disease phenotypes, but studies must be done to confirm their role.
G-Quadruplex Formation Within SLC6A3, a Potentially Relevant Finding to Substance Use Disorder
Kathleen Cardone and Evan Buck
Major:
Biobehavioral Health
Exhibition Category:
Health and Life Sciences
Exhibition Format:
Poster Presentation
Campus:
University Park
Faculty Sponsor:
David Vandenbergh
Poster Number:
16993
Award Winner
University Library Awards for Information Literacy - Honorable Mention