Late Embryogenesis Abundant (LEA) proteins are most commonly known for their tolerance of desiccation and high salt concentrations in living organisms due to their hydrophilic properties and formation of amphipathic alpha helices. Provided this functionality and challenges in the vitrification process of cryo-EM, incorporation of LEA proteins in the freezing of samples could potentially allow it to act as a cryo-protective agent to reduce crystalline ice formation and prevent sample degradation through molecular shielding.