This project examines the utility of a polygenic risk score in predicting BMI as an obesity measure within Hispanics/Latinos, with consideration for health insurance status as a gene-by-environment interaction factor. We observe that immigration and health insurance status modify the association between polygenic risk score and BMI in Hispanics/Latinos. Our findings describe within-group disparities in obesity in Hispanic/Latinos and inform that health insurance and immigrant history are factors that modify disease risk in diverse populations.