Injury to most neurons resulting in damage to the axon causes lifelong nerve damage. However, peripheral neurons regenerate their axons after injury and could reveal potential treatments for nerve damage. Previous research revealed the smooth endoplasmic reticulum (SER) plays a vital, but unknown role in axon regeneration after injury. My research studies the purpose of the SER in axon regeneration, investigating its role in calcium storage and release through the calcium channel, Ryanodine receptor.