Increased expression of the CD36 scavenger receptor has been correlated with poor prognosis in breast cancer patients, but the role of CD36 in cancer progression is not well understood. Using a doxycycline-inducible overexpression system, we find that CD36 promotes breast cancer cell migration and hallmarks of epithelial to mesenchymal transition (EMT), which could enhance cancer metastasis. These findings suggest that CD36 overexpression enhances aggressive cancer cell features and could contribute to metastasis.