We identified relationships between food insecurity (FI), physical activity (PA), and anxiety in 919 college students. Aims: 1) explore whether FI is related to anxiety, and 2) examine if PA moderates the FI-anxiety relationship before and during COVID-19. FI was related to 2.69 times increased odds of anxiety before COVID-19 (95% CI:1.98-3.66) and to 1.91 times increased odds of anxiety during COVID-19 (95% CI: 1.32-2.78). We did not find PA to be a significant moderator variable (p=0.09).