Spindle matrix proteins (e.g. Skeletor, Megator, and Chromator) and kinetochore proteins (e.g. Mad1), which are known to interact with microtubules during mitosis, are suspected to regulate microtubules in postmitotic neurons. Previous work from the Rolls Lab shows that knockdown of both SM and KT proteins results in increased microtubule dynamics in dendrites. Using RNAi, colocalization, live imaging, and injury assays, we intend to uncover any interactions between SM proteins, KT proteins, and neuronal microtubules.