Purine metabolic disorders are genetic disorders associated with severe neurological symptoms. When DNA in purine metabolism is mutated, there is an accumulation of intermediates, leading to abnormal phenotypes in affected individuals. F38B6.4 is the Caenorhabditis elegans ortholog to human GART, a gene located on the 21st chromosome involved with three steps of purine metabolism, as well as linked to Down syndrome. RNAi was used to knockdown gene function, and the resulting reversal phenotypes were assessed.