The dysfunction and destabilization of microtubules has been linked to the development of neurodegenerative diseases. Microtubules are polymers of tubulin that form the cytoskeleton of cells and provide cell structure and integrity. Microtubules are required throughout the life of a neuron to maintain shape and to facilitate the transport of substances across axons and dendrites. The molecular mechanisms behind the stability of microtubules in neurons is not well understood.