Health protective behaviors (HPBs) are critical to slowing the spread of viruses like COVID-19. In this study, we utilized a sample of 204 families to examine how family structure was associated with HPB adherence across 48 weeks of the COVID-19 pandemic. Results demonstrated family structure was not correlated with parent or child HPB adherence. Paired samples t-tests showed that parent and child HPB adherence were significantly lower in May 2021 compared to April 2020.