Excessive alcohol consumption is a major public health crisis with a myriad of negative implications. The prefrontal cortex (PFC) has been demonstrated to be deeply associated with alcohol misuse. Somatostatin neurons within the PFC are fundamentally involved with binge drinking behaviors. However, somatostatin’s mechanistic role in binge drinking is not well understood. Using a well-validated rodent binge-drinking model, I elucidate the effect of binge alcohol consumption on somatostatin cell number expression and signaling.