The Role of Cytoplasmic Domain Contacts in the Functional Interaction Between the Voltage Sensor and Pore of Elk Family Potassium Channels

Voltage-gated ion channels are comprised of a functionally independent voltage sensor and pore that interact during depolarized membrane potentials to conduct an ion current. Even when the peptide linkage between these structures is severed, the channel retains its function, suggesting the presence of other non-covalent interactions that further stabilize the channel. This research investigates whether physical contact with the N-terminal cytoplasmic domain is utilized to maintain the gating ability of Elk family potassium ion channels.