New Zealand mud snails (NZMS), Potamopyrgus antipodarum, are a highly invasive aquatic gastropod that have become established in multiple drainages in Pennsylvania. While data exists on physical and chemical factors that influence their abundance, few of these studies have focused on NZMS in the Eastern US. This study measured pH, conductivity, the concentrations of magnesium and calcium ions, phosphate, and nitrate in the Spring Creek watershed in Centre County, PA in May and July of 2022 and related those variables to NZMS density. To conduct the research, water samples were taken from Spring Creek and its tributaries at five sites and tested using LaMotte water testing kits, a LaMotte SMART colorimeter, and Vernier electrodes. NZMS density was estimated from core samples taken from each site. Results show significant positive correlations between NZMS density and pH and concentrations of calcium in Spring Creek in July. These results are consistent with the expectations that calcium can be a limiting nutrient for mollusks and pH can influence shell growth.