Age-Specific Effects of NAD+ Precursors on Vitality in Caenorhabditis elegans

Nicotinamide Adenine Dinucleotide (NAD+), is an essential coenzyme to key metabolic pathway and declines with age. This phenomenon is associated with various hallmarks of aging and raises questions about supplementing declining NAD+ levels. Although NAD+ precursor supplementation has become popular in recent years, its impact remains poorly understood. Thus, this study investigates the impact of two NAD+ precursors that drive NAD+ synthesis in C. elegans: Nicotinic Acid (NA) and Nicotinamide (NAM).