Applying Cumulative Disadvantage Theory to Understand Adversity across the Lifespan and Later Life Inflammation

The theoretical perspectives of allostatic load and cumulative disadvantage can be used in tandem to consider the impact accumulated early and adult adversity has on health. We tested associations between early life and adulthood adversity on inflammation in the Einstein Aging Study (N = 205, Age Range = 70-89) with race as a moderator. Using regression and correlational models, significant effects were seen for adult/early life adversity and IL6, TNF- Î±, race modified associations.