Core-shell commensal biocapsules for in situ gut microbiome engineering

The human microbiome harbors commensal bacteria essential for bodily function. Current broad-spectrum antibiotics disrupt microbiome balance, rendering the body vulnerable. To address this, peptide-carbohydrate biocapsules were fabricated. These biocapsules are loaded with commensal bacteria and feature an antimicrobial coating, exhibiting potential to re-engineer the microbiome instead of disrupting it. The biocapsules target pathogenic growth while selectively releasing beneficial bacteria at infection sites. This biomaterial could revolutionize microbiome interventions, laying the foundation for broader health benefits.