Dysregulation of the NAD+ Metabolome in Acute Kidney Injury (AKI)

To investigate ways of promoting healthier aging in an increasingly older world population, this study focuses on essential coenzyme, Nicotinamide Adenine Dinucleotide (NAD+), which has been implicated in aging and stress. Increased occurrence of Acute Kidney Injury (AKI) is associated with both aging and decline of NAD+ pools throughout the body. Whole body metabolic profiling amidst AKI reveals various deficiencies in NAD+ synthesis and an accelerated consumption rate, offering insights for potentially targeting age-related diseases.