Some long non-coding RNAs (lncRNAs) are known to contain structures important for function. Single nucleotide polymorphisms (SNPs) have the potential to alter these structures and thus impact function. We have predicted structurally altering SNPs, known as riboSNitches, from the 1000 Genomes Project in human lncRNAs. Currently, we are working to uncover putative functionally relevant structures by looking for lncRNAs with depleted levels of riboSNitches.