Plasmodium falciparum is the deadliest human malaria-causing parasite. In vivo, P. falciparum requires human serum metabolites to reproduce within red blood cells, and it is also known that the composition of serum metabolites varies between humans. However, our understanding remains incomplete as to how this variation impacts P. falciparum growth. We aim to identify naturally variable human serum metabolites impacting the growth of P. falciparum, toward informing the discovery of novel antimalarial treatments.