Investigating the inhibition of trans-translation in Streptococcus mitis by MBX-4204

Hannah Bauer

Streptococcus mitis is an opportunistic pathogen that is resistant to common antibiotics. The Keiler Lab has identified 46 small molecule inhibitors that block the trans-translation pathway in bacteria. KKL-35, a small molecule inhibitor, was found to be active at 2.5 µM in a S. mitis culture. An in vitro trans-translation assay would be able to confirm if MBX-4204 inhibits trans-translation in S. mitis, and therefore would be a good antibiotic candidate.

Major: 
Biochemistry and Molecular Biology
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Ken Keiler
Poster Number: 
93

Award Winner

University Fellowships and Phi Kappa Phi Peter T. Luckie Awards for Outstanding Juniors Winner