Investigating Spindle Matrix Proteins and Microtubule Dynamics in the Neuronal Injury Response

Nathaniel Carey

Neurons depend on microtubules (MTs) for intracellular transport, signaling, and structure. Spindle matrix (SM) proteins work closely with spindle MTs during mitosis, and we suspect they may also regulate MTs in neurons. After axon injury, we have documented an increase in MTs, and I have observed a subsequent decrease in the SM protein Chromator. Using RNAi, mutant genotypes, and fluorescence microscopy, I am investigating this relationship and possible communication pathways between SM proteins and MTs.

Major: 
Biotechnology/Department of Biochemistry and Molecular Biology
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Melissa Rolls
Poster Number: 
65