As we age, decreasing levels of NAD+ (Nicotinamide Adenine Dinucleotide) can lead to age-related complications such as acute kidney injury (AKI). Onset of AKI can lead to chronic kidney disease, kidney failure, and death. To tackle this relationship, we induced AKI in mouse models to investigate NAD+ biology. We quantified metabolic shifts using LCMS and mapped the expression of genes using qRT-PCR. Investigating AKI and dysregulation of NAD+ provided valuable insights into disease susceptibility.
Mapping expression of NAD+ metabolic genes in a mouse model of acute kidney injury
Isaiah Diggs
Major:
Biochemistry and Molecular Biology
Exhibition Category:
Health and Life Sciences
Exhibition Format:
Poster Presentation
Campus:
University Park
Faculty Sponsor:
Melanie McReynolds
Poster Number:
134