Used in traditional Ethiopian medicine Dovyalis abyssinica is known to have anticancer effects. To isolate the anticancer compounds of this plant, crude extracts were separated using flash chromatography and their cytotoxicity was determined using the in-vitro MTT assay on two cancer cell lines. Mass spectrometry-linked biochemometric modeling was undergone to identify the cytotoxic compounds and their structures. Ultimately, however, more testing needs to take place to definitively elucidate the chemical structures as results were inconclusive.