The World Health Organization has acknowledged the growing use of traditional plant-based medicines, highlighting their potential as sources of new therapeutic agents, particularly in the context of antimicrobial resistance (AMR), a critical global health issue fueled by the overuse and misuse of antibiotics. Numerous plant-derived compounds have shown promise in combating drug resistance. Secondary metabolites, such as alkaloids, terpenoids, and phenolics, possess antimicrobial properties that disrupt bacterial cell functions via various mechanisms, thereby preventing bacterial survival and mitigating the likelihood of resistance development. These plant-based bioactive compounds demonstrate significant efficacy against a wide range of pathogens, including drug-resistant bacteria, fungi, protozoa, and viruses. This research aims to explore recent advancements in extraction methods, genetic manipulation, and the standardization of testing protocols, which together offer exciting opportunities to unlock the full therapeutic potential of medicinal plants in addressing antimicrobial resistance.