Development and testing a gene therapy for the Wolcott Rallison Syndrome in a mouse model

Payten Gorman and Rulin Zheng

We have developed mouse model of WRS by generating a hypomorphic mutation in the PERK (EIF2AK3) gene. By genetic crosses we are generating mice that are homozygous for the PERK hypomorphic mutation. During this semester human islet-like organoids will be transplanted into these mice to determine if they can rescue their severe diabetes.

Major: 
Biology
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Douglas Cavener
Poster Number: 
41