As Watson and Crick determined, RNA has predictable base pairings. These pairs occur in the following standard pairs: A–U, G–C, and G•U, with our study focusing on the G•U base pair. However, to enhance structural diversity, RNA can also adopt rare base-pairing orientations that may involve charged or tautomeric states of residues. Analyzing these wobble pairs allows us to investigate the forces behind their structure formation and the interactions within them.