Malaria, a global disease characterized by fever, fatigue, and potential fatality, is caused by parasites of the genus Plasmodium. This research investigates the roles of specialized S-Type ribosomes (S1 and S2) within the Plasmodium life cycle. Using molecular cloning techniques, we modify plasmids derived from the Plasmodium genome with 3xMango-II tags. These RNA tags provide a physical 'handle' for us to remove the ribosomes from the parasites and study them in isolation.