Plasmodium falciparum is the deadliest human malaria-causing parasite. In vivo, P. falciparum relies on human serum metabolites to reproduce within red blood cells, and it is known that the composition of serum metabolites varies between humans. However, it is not fully understood how this variation impacts P. falciparum growth. We aim to identify naturally variable human serum metabolites impacting the growth of P. falciparum, with the goal of informing the discovery of novel antimalarial treatments.